换一批Zoledronate in the prevention of Paget's (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent <i>SQSTM1</i>-mediated Paget's disease of bone.
第一作者：
Owen,Cronin
第一单位：
Department of Rheumatology, Western General Hospital, Edinburgh, UK.
作者：
Owen,Cronin [1]
;
Laura,Forsyth [2]
;
Kirsteen,Goodman [3]
;
Steff C,Lewis [2]
;
Catriona,Keerie [2]
;
Allan,Walker [2]
;
Mary,Porteous [4]
;
Roseanne,Cetnarskyj [5]
;
Lakshminarayan R,Ranganath [6]
;
Peter L,Selby [7]
;
Geeta,Hampson [8]
;
Rama,Chandra [9]
;
Shu,Ho [10]
;
Jon H,Tobias [11]
;
Steven,Young-Min [12]
;
Malachi J,McKenna [13]
;
Rachel K,Crowley [13]
;
William D,Fraser [14]
;
Luigi,Gennari [15]
;
Ranuccio,Nuti [15]
;
Maria Luisa,Brandi [16]
;
Javier,Del Pino-Montes [17]
;
Jean-Pierre,Devogelaer [18]
;
Anne,Durnez [19]
;
Giancarlo,Isaia [20]
;
Marco,Di Stefano [20]
;
Núria,Guañabens [21]
;
Josep,Blanch [22]
;
Markus J,Seibel [23]
;
John P,Walsh [24]
;
Mark A,Kotowicz [25]
;
Geoffrey C,Nicholson [26]
;
Emma L,Duncan [27]
;
Gabor,Major [28]
;
Anne,Horne [29]
;
Nigel L,Gilchrist [30]
;
Maarten,Boers [31]
;
Gordon D,Murray [32]
;
Keith,Charnock [33]
;
Diana,Wilkinson [33]
;
R Graham G,Russell [34]
;
Stuart H,Ralston [35]
作者单位：
Department of Rheumatology, Western General Hospital, Edinburgh, UK.
[1]
Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
[2]
Glasgow Caledonian University School of Nursing Midwifery and Community Health, Glasgow, UK.
[3]
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
[4]
University of Dundee - Fife Campus, Kirkcaldy, UK.
[5]
University of Liverpool, Liverpool, UK.
[6]
University of Manchester, Manchester, UK.
[7]
Guy's and St Thomas' NHS Trust, London, UK.
[8]
King's College Hospital, London, UK.
[9]
Robert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, UK.
[10]
Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[11]
Portsmouth Hospitals NHS Trust, Portsmouth, UK.
[12]
University College Dublin, Dublin, Ireland.
[13]
Department of Medicine Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
[14]
University of Siena Faculty of Medicine and Surgery, Siena, Italy.
[15]
University Hospital Careggi, Firenze, Italy.
[16]
University Hospital of Salamanca, Salamanca, Spain.
[17]
Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
[18]
Rheumatology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.;Algemeen Ziekenhuis Jan Portaels, Vilvoorde, Belgium.
[19]
Università degli Studi di Torino, Torino, Piemonte, Italy.
[20]
Rheumatology Department, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
[21]
Hospital del Mar, Barcelona, Catalunya, Spain.
[22]
Concord Repatriation General Hospital, Sydney, New South Wales, Australia.;Bone Research Program, ANZAC Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
[23]
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.;Medical School, The University of Western Australia, Crawley, Western Australia, Australia.
[24]
Department of Endocrinology and Diabetes, Barwon Health, Geelong, Victoria, Australia.
[25]
Rural Clinical School, University of Queensland, Toowoomba, Queensland, Australia.
[26]
Department of Endocrinology and Diabetes, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.;Faculty of Medicine, University of Queensland, Herston, Queensland, Australia.;Translational Genomics Group, Institute of Health and Biomedical Innovation, Faculty of Health, Queensland University of Technology, Woolloongabba, Queensland, Australia.
[27]
Royal Newcastle Centre John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.
[28]
Department of Medicine, University of Auckland, Auckland, New Zealand.
[29]
GCM Research Trust, Burnwood Hospital, Christchurch, New Zealand.
[30]
Epidemiology & Biostatistics, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands.
[31]
Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
[32]
The Paget's Association, Manchester, UK.
[33]
Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.
[34]
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK stuart.ralston@ed.ac.uk.
[35]
医学主题词
成年人(Adult);焦虑(Anxiety);骨密度保护剂(Bone Density Conservation Agents);抑郁(Depression);基因检测(Genetic Testing);人类(Humans);突变(Mutation);变形性骨炎(Osteitis Deformans);生活质量(Quality of Life);放射性核素显像(Radionuclide Imaging);随机对照试验(主题)(Randomized Controlled Trials as Topic)
DOI
10.1136/bmjopen-2019-030689
PMID
31488492
发布时间
2023-10-13
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