Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.

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作者： Jacopo,Agrimi ^[1] ; Cristina,Spalletti ^[2] ; Carlotta,Baroni ^[3] ; Gizem,Keceli ^[4] ; Guangshuo,Zhu ^[4] ; Angela,Caragnano ^[5] ; Marco,Matteucci ^[3] ; Stephen,Chelko ^[4] ; Genaro A,Ramirez-Correa ^[6] ; Djahida,Bedja ^[4] ; Valentina,Casieri ^[3] ; Nicole,Di Lascio ^[7] ; Arianna,Scalco ^[8] ; Antonio Paolo,Beltrami ^[5] ; Nazareno,Paolocci ^[9] ; Matteo,Caleo ^[10] ; Vincenzo,Lionetti ^[11]

作者单位： Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy; Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA. ^[1] CNR Neuroscience Institute, Pisa 56124, Italy. ^[2] Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy. ^[3] Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA. ^[4] Department of Medicine (DAME), University of Udine, Udine 33100, Italy. ^[5] Department of Molecular Science, UT Health Rio Grande Valley 5300 N L Street/Office 1.48 McAllen, Texas 78502, USA. ^[6] Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy; CNR Institute of Clinical Physiology, Pisa 56124, Italy. ^[7] Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128 Padova, Italy. ^[8] Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Sciences, University of Padova, Padova 35131, Italy. ^[9] CNR Neuroscience Institute, Pisa 56124, Italy; Department of Biomedical Sciences, University of Padova, Padova 35131, Italy. ^[10] Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy; UOS Anesthesiology and Intensive Care Medicine, Fondazione Toscana G. Monasterio, Pisa 56124, Italy. Electronic address: v.lionetti@santannapisa.it. ^[11]

关键词 Brain-derived neurotrophic factor (BDNF)Brain-heart axis Hippocampus Left ventricle Obesity Oxidative stress Psychosocial stress Tropomyosin receptor kinase B (TrkB)

主题词动物(Animals);细胞凋亡(Apoptosis);行为, 动物(Behavior, Animal);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);共病现象(Comorbidity);超声心动描记术(Echocardiography);纤维化(Fibrosis);海马(Hippocampus);男(雄)性(Male);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);小鼠, 肥胖(Mice, Obese);心肌(Myocardium);神经发生(Neurogenesis);氧化性应激(Oxidative Stress);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);活性氧(Reactive Oxygen Species);应激, 心理学(Stress, Psychological)

DOI 10.1016/j.ebiom.2019.08.042

PMID 31492565

发布时间 2023-01-13

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2019年47卷

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Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.

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Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion.

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