mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.-论文-万方医学网

作者： Florian,Beaumatin ^[1] ; Jim,O'Prey ^[1] ; Valentin J A,Barthet ^[2] ; Barbara,Zunino ^[1] ; Jean-Philippe,Parvy ^[1] ; Alexis Maximilien,Bachmann ^[1] ; Margaret,O'Prey ^[1] ; Elżbieta,Kania ^[1] ; Pablo Sierra,Gonzalez ^[2] ; Robin,Macintosh ^[1] ; Laurence Y,Lao ^[1] ; Colin,Nixon ^[1] ; Jonathan,Lopez ^[2] ; Jaclyn S,Long ^[1] ; Stephen W G,Tait ^[2] ; Kevin M,Ryan ^[3]

作者单位： Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. ^[1] Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. ^[2] Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.ryan@beatson.gla.ac.uk. ^[3]

主题词 3T3-L1细胞(3T3-L1 Cells);脂细胞(Adipocytes);成脂分化(Adipogenesis);氨基酸转运系统ASC(Amino Acid Transport System ASC);氨基酸转运系统y+L(Amino Acid Transport System y+L);氨基酸类(Amino Acids);动物(Animals);血糖(Blood Glucose);载体蛋白质类(Carrier Proteins);能量代谢(Energy Metabolism);酶激活(Enzyme Activation);HEK293细胞(HEK293 Cells);人类(Humans);胰岛素(Insulin);大分子中性氨基酸转运子1(Large Neutral Amino Acid-Transporter 1);溶酶体(Lysosomes);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);次要组织相容性抗原(Minor Histocompatibility Antigens);蛋白质转运(Protein Transport)

DOI 10.1016/j.molcel.2019.07.021

PMID 31492633

发布时间 2024-02-10

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.

Molecular cell

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Molecular cell

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.

Molecular cell

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Molecular cell

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