Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures.

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作者： Clara,Grudina ^[1] ; Georgia,Kouroupi ^[2] ; Takashi,Nonaka ^[3] ; Masato,Hasegawa ^[3] ; Rebecca,Matsas ^[2] ; Chiara,Zurzolo ^[4]

作者单位： Unité de Traffic Membranaire et Pathogénèse, Institut Pasteur, 28 Rue du Dr. Roux, Paris 75015, France. ^[1] Laboratory of Cell and Molecular Neurobiology - Stem Cells, Department of Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 11521, Greece. ^[2] Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8585, Japan. ^[3] Unité de Traffic Membranaire et Pathogénèse, Institut Pasteur, 28 Rue du Dr. Roux, Paris 75015, France. Electronic address: chiara.zurzolo@pasteur.fr. ^[4]

关键词 Alpha-synuclein Human neuronal precursors Lysosomes Parkinson's disease TNT-like structures

主题词细胞间通讯(Cell Communication);胞吞作用(Endocytosis);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);溶酶体(Lysosomes);神经干细胞(Neural Stem Cells);α突触核蛋白(alpha-Synuclein)

DOI 10.1016/j.nbd.2019.104609

PMID 31494284

发布时间 2020-08-06

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