Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.

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第一作者： Elisabetta,Teodori

第一单位： Department of Neuroscience, Psychology, Drug Research and Child's Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, via Ugo Schiff 6, 50019, Sesto Fiorentino, FI, Italy. Electronic address: elisabetta.teodori@unifi.it.

作者： Elisabetta,Teodori ^[1] ; Marialessandra,Contino ^[2] ; Chiara,Riganti ^[3] ; Gianluca,Bartolucci ^[4] ; Laura,Braconi ^[4] ; Dina,Manetti ^[4] ; Maria Novella,Romanelli ^[4] ; Alfonso,Trezza ^[5] ; Asimidis,Athanasios ^[5] ; Ottavia,Spiga ^[5] ; Maria Grazia,Perrone ^[2] ; Roberta,Giampietro ^[2] ; Elena,Gazzano ^[3] ; Milena,Salerno ^[6] ; Nicola Antonio,Colabufo ^[2] ; Silvia,Dei ^[4]

作者单位： Department of Neuroscience, Psychology, Drug Research and Child's Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, via Ugo Schiff 6, 50019, Sesto Fiorentino, FI, Italy. Electronic address: elisabetta.teodori@unifi.it. ^[1] Department of Pharmacy-Drug Sciences, University of Bari "A. Moro", via Orabona 4, 70125, Bari, Italy. ^[2] Department of Oncology, University of Turin, Via Santena 5/bis, 10126, Torino, Italy. ^[3] Department of Neuroscience, Psychology, Drug Research and Child's Health - Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, via Ugo Schiff 6, 50019, Sesto Fiorentino, FI, Italy. ^[4] Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100, Siena, Italy. ^[5] Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS (UMR 7244), UFR-SMBH, 74 rue Marcel Cachin, 93017, Bobigny, France. ^[6]

关键词 Collateral sensitivity Enantiomers Human plasma stability K562?cells MDCK cells MDR reversers Molecular docking P-gp modulators