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Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate.

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第一作者： Yu,Ke

第一单位： School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China.

作者： Yu,Ke ^[1] ; Tian-Xing,Hu ^[1] ; Jun-Feng,Huo ^[1] ; Jun-Ke,Yan ^[1] ; Jin-Yi,Wang ^[1] ; Rui-Hua,Yang ^[1] ; Hang,Xie ^[1] ; Ying,Liu ^[1] ; Ni,Wang ^[1] ; Zi-Jun,Zheng ^[1] ; Ya-Xin,Sun ^[1] ; Cong,Wang ^[2] ; Juan,Du ^[3] ; Hong-Min,Liu ^[4]

作者单位： School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. ^[1] School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address: wangcong@zzu.edu.cn. ^[2] School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address: dujuan2004@zzu.edu.cn. ^[3] School of Pharmaceutical Sciences, Institute of Drug Discovery and Development, Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Zhengzhou University, Zhengzhou, 450001, PR China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China. Electronic address: liuhm@zzu.edu.cn. ^[4]

关键词 Anti-proliferative activity Ent-kaurene diterpene Isodon plants ROS/JNK/Bcl-2 pathway Solubility