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首页> Neurobiology of disease> Sex-dependent impaired locomotion and motor coordination in the HdhQ200/200 mouse model of Huntington's Disease.

Sex-dependent impaired locomotion and motor coordination in the HdhQ200/200 mouse model of Huntington's Disease.

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作者： Jessica K,Cao ^[1] ; Katie,Viray ^[1] ; Larry,Zweifel ^[2] ; Nephi,Stella ^[3]

作者单位： Department of Pharmacology, University of Washington, Seattle, WA, United States of America. ^[1] Department of Pharmacology, University of Washington, Seattle, WA, United States of America; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA, United States of America. ^[2] Department of Pharmacology, University of Washington, Seattle, WA, United States of America; Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA, United States of America. Electronic address: nstella@uw.edu. ^[3]

关键词 Behavior Excitotoxicity Huntington's Disease Mouse models Neurodegeneration Polyglutamine disease Protein aggregation

主题词动物(Animals);星形细胞(Astrocytes);共济失调(Ataxia);纹状体(Corpus Striatum);疾病模型, 动物(Disease Models, Animal);兴奋性氨基酸转运子2(Excitatory Amino Acid Transporter 2);女(雌)性(Female);步态障碍, 神经性(Gait Disorders, Neurologic);杭廷顿病(Huntington Disease);移动(Locomotion);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经元(Neurons);精神运动性行为(Psychomotor Performance);性征(Sex Characteristics)

DOI 10.1016/j.nbd.2019.104607

PMID 31499139

发布时间 2021-03-13

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