In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice.

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作者： Xirong,Zheng ^[1] ; Linyue,Shang ^[1] ; Chang-Guo,Zhan ^[2] ; Fang,Zheng ^[3]

作者单位： Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. ^[1] Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. Electronic address: zhan@uky.edu. ^[2] Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA. Electronic address: fzhen2@uky.edu. ^[3]

关键词 Cocaine metabolite Cocaine toxicity Concurrent use of cocaine and alcohol Drug metabolism Norcocaethylene

主题词动物(Animals);可卡因(Cocaine);剂量效应关系, 药物(Dose-Response Relationship, Drug);半数致死量(Lethal Dose 50);移动(Locomotion);男(雄)性(Male);小鼠(Mice)

DOI 10.1016/j.drugalcdep.2019.04.033

PMID 31499241

发布时间 2020-12-16

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