Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.

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作者： Jeffrey P,Bonin ^[1] ; Paul J,Sapienza ^[2] ; Emily,Wilkerson ^[3] ; Dennis,Goldfarb ^[4] ; Li,Wang ^[1] ; Laura,Herring ^[3] ; Xian,Chen ^[5] ; Michael B,Major ^[6] ; Andrew L,Lee ^[7]

作者单位： Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[1] Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[2] Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[3] Michael Hooker Proteomics Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[4] Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[5] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ^[6] Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: drewlee@unc.edu. ^[7]