首页> European heart journal> Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores.

Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores.

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第一作者： Rafik,Tadros

第一单位： Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands.;Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, 5000 Belanger, Montreal, QC, Canada.

作者： Rafik,Tadros ^[1] ; Hanno L,Tan ^[2] ; ESCAPE-NET Investigators ^[2] ; Sulayman,El Mathari ^[3] ; Jan A,Kors ^[2] ; Pieter G,Postema ^[2] ; Najim,Lahrouchi ^[2] ; Leander,Beekman ^[4] ; Milena,Radivojkov-Blagojevic ^[2] ; Ahmad S,Amin ^[5] ; Thomas,Meitinger ^[6] ; Michael W,Tanck ^[7] ; Arthur A,Wilde ^[2] ; Connie R,Bezzina

作者单位： Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands.;Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, 5000 Belanger, Montreal, QC, Canada. ^[1] Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands. ^[2] Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, GD Rotterdam, The Netherlands. ^[3] Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, Germany. ^[4] Institute of Human Genetics, Helmholtz Zentrum München, Ingolstädter Landstraße 1, Neuherberg, Germany.;Institute of Human Genetics, Technical University of Munich, Trogerstraße 32, Munich, Germany. ^[5] Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, AZ Amsterdam, The Netherlands. ^[6] Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ Amsterdam, The Netherlands.;Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, 7393 Al-Malae'b St, King Abdul Aziz University, Jeddah, Saudi Arabia. ^[7]

关键词 Ajmaline Brugada syndrome PR Polygenic risk score QRS