Regioselective Glycosylation Strategies for the Synthesis of Group Ia and Ib Streptococcus Related Glycans Enable Elucidating Unique Conformations of the Capsular Polysaccharides.

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作者： Linda,Del Bino ^[1] ; Ilaria,Calloni ^[2] ; Davide,Oldrini ^[1] ; Maria Michelina,Raso ^[1] ; Rossella,Cuffaro ^[1] ; Ana,Ardá ^[2] ; Jeroen D C,Codée ^[3] ; Jesús,Jiménez-Barbero ^[2] ; Roberto,Adamo ^[4]

作者单位： GSK, Via Fiorentina 1, 53100, Siena, Italy. ^[1] CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160, Derio, Spain. ^[2] Department of Bioorganic Synthesis, Leiden University, 2333, Leiden, The Netherlands. ^[3] Basque Foundation for Science IKERBASQUE, 8009, Bilbao, Spain. ^[4] Department of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country, 48940, Leioa, Spain. ^[5]

关键词 carbohydrates conformation analysis glycosylation regioselectivity therapeutics

主题词细菌荚膜(Bacterial Capsules);葡糖胺(Glucosamine);糖基化(Glycosylation);分子构象(Molecular Conformation);多糖类, 细菌(Polysaccharides, Bacterial);立体异构现象(Stereoisomerism);链球菌属(Streptococcus)

DOI 10.1002/chem.201903527

PMID 31506992

发布时间 2023-11-13

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