首页> The Journal of allergy and clinical immunology> Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells.

Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells.

导出 OA

翻译打印收藏纠错

第一作者： Marie,Pouzolles

第一单位： Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.

作者： Marie,Pouzolles ^[1] ; Alice,Machado ^[1] ; Mickaël,Guilbaud ^[2] ; Magali,Irla ^[3] ; Sarah,Gailhac ^[1] ; Pierre,Barennes ^[4] ; Daniela,Cesana ^[5] ; Andrea,Calabria ^[5] ; Fabrizio,Benedicenti ^[5] ; Arnauld,Sergé ^[6] ; Indu,Raman ^[7] ; Quan-Zhen,Li ^[8] ; Eugenio,Montini ^[5] ; David,Klatzmann ^[9] ; Oumeya,Adjali ^[10] ; Naomi,Taylor ^[11] ; Valérie S,Zimmermann ^[12]

作者单位： Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France. ^[1] INSERM UMR1089, Université de Nantes, Centre Hospitalier Universitaire de Nantes, Nantes, France. ^[2] Center of Immunology Marseille-Luminy (CIML), INSERM U1104, CNRS UMR7280, Aix-Marseille Université UM2, Marseille, France. ^[3] Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France. ^[4] San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS, San Raffaele Scientific Institute, Milan, Italy. ^[5] Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France. ^[6] Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, Tex. ^[7] Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, Tex; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Tex. ^[8] Sorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), Paris, France; AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France. ^[9] INSERM UMR1089, Université de Nantes, Centre Hospitalier Universitaire de Nantes, Nantes, France. Electronic address: oumeya.adjali@univ-nantes.fr. ^[10] Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md. Electronic address: taylorn4@mail.nih.gov. ^[11] Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France. Electronic address: zimmermann@igmm.cnrs.fr. ^[12]

关键词 Severe combined immunodeficiency T-cell reconstitution gene therapy humoral immunity intrathymic gene transfer medulla formation thymus zeta-associated protein of 70kDa