PEGylated lipid bilayer coated mesoporous silica nanoparticles co-delivery of paclitaxel and curcumin leads to increased tumor site drug accumulation and reduced tumor burden.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);生物转运(Biological Transport);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);姜黄素(Curcumin);狗(Dogs);药物调剂(Drug Compounding);药物疗法, 联合(Drug Therapy, Combination);女(雌)性(Female);人类(Humans);脂双层(Lipid Bilayers);溶酶体(Lysosomes);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);线粒体(Mitochondria);纳米囊(Nanocapsules);紫杉酚(Paclitaxel);聚乙烯二醇类(Polyethylene Glycols);多孔性(Porosity);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);二氧化硅(Silicon Dioxide);表面特性(Surface Properties);肿瘤负荷(Tumor Burden)
DOI
10.1016/j.ejps.2019.105070
PMID
31518679
发布时间
2020-01-22
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