Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE<sup>-/-</sup> mice.

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作者： Ge,Tang ^[1] ; Fengqi,Duan ^[1] ; Weixuan,Li ^[1] ; Yiqin,Wang ^[1] ; Cheng,Zeng ^[1] ; Jia,Hu ^[1] ; Hongyu,Li ^[2] ; Xuanhong,Zhang ^[2] ; Yanming,Chen ^[3] ; Hongmei,Tan ^[4]

作者单位： Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. ^[1] Laboratory Animal Center, Sun Yat-sen University, Guangzhou 510080, China. ^[2] Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, 510630, China. Electronic address: chyanm@mail.sysu.edu.cn. ^[3] Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Laboratory Animal Center, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: tanhm@mail.sysu.edu.cn. ^[4]

关键词 Atherosclerosis Metformin NLRP3 inflammasomes

主题词腺苷酸激酶(Adenylate Kinase);动物(Animals);主动脉(Aorta);载脂蛋白E类(Apolipoproteins E);动脉粥样硬化(Atherosclerosis);血糖(Blood Glucose);载体蛋白质类(Carrier Proteins);糖尿病(Diabetes Mellitus);酶激活(Enzyme Activation);高血糖症(Hyperglycemia);高脂血症(Hyperlipidemias);炎性体(Inflammasomes);脂类(Lipids);巨噬细胞(Macrophages);男(雄)性(Male);二甲双胍(Metformin);小鼠, 近交C57BL(Mice, Inbred C57BL);活性氧(Reactive Oxygen Species);硫氧还蛋白质类(Thioredoxins)

DOI 10.1016/j.biopha.2019.109410

PMID 31518877

发布时间 2020-02-25

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019年119卷

109410页

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Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE<sup>-/-</sup> mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE<sup>-/-</sup> mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

相似文献

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

相关期刊

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