Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells.

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作者： Yibing,Chen ^[1] ; Yanjun,Mi ^[2] ; Xiaofei,Zhang ^[3] ; Qian,Ma ^[1] ; Yucen,Song ^[1] ; Liwei,Zhang ^[4] ; Dandan,Wang ^[5] ; Jinliang,Xing ^[6] ; Benxin,Hou ^[7] ; Haolong,Li ^[8] ; Huan,Jin ^[8] ; Wei,Du ^[9] ; Zhengzhi,Zou ^[10]

作者单位： Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. ^[1] Department of Medical Oncology, Xiamen Cancer Hospital, First Affiliated Hospital of Xiamen University, Xiamen, 361003, China. ^[2] Department of Medical Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. ^[3] Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. ^[4] Shandong Medicinal Biotechnology Centre, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Back and Neck Pain Hospital of Shandong Academy of Medical Sciences, Shandong Academy of Medical Sciences, Jinan, 250062, China. ^[5] State Key Laboratory of Cancer Biology & Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China. ^[6] Department of General Surgery, Hainan Province Nongken Sanya Hospital, Sanya, 572000, China. ^[7] MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, Guangdong, China. ^[8] Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China. duwei@zzu.edu.cn. ^[9] MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, Guangdong, China. zouzhengzhi@m.scnu.edu.cn. ^[10]

关键词 Dihydroartemisinin Endoplasmic reticulum stress Ferroptosis GPX4 Glioma HSPA5