Autoantibodies to protein-arginine deiminase (PAD) 4 in rheumatoid arthritis: immunological and clinical significance, and potential for precision medicine.

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作者： Laura,Martinez-Prat ^[1] ; Boaz,Palterer ^[2] ; Gianfranco,Vitiello ^[3] ; Paola,Parronchi ^[4] ; William H,Robinson ^[5] ; Michael,Mahler ^[6]

作者单位： Research and Development, Inova Diagnostics , San Diego , CA , USA. ^[1] Department of Experimental Science, Francisco de Vitoria University , Madrid , Spain. ^[2] specialist in Allergy and Clinical Immunology, Experimental and Clinical Medicine Department, University of Florence , Florence , Italy. ^[3] resident in Allergy and Clinical Immunology, Experimental and Clinical Medicine Department, University of Florence , Florence , Italy. ^[4] (Allergy and Clinical Immunology), Laboratory Head, Experimental and Clinical Medicine Department, University of Florence , Florence , Italy. ^[5] (Immunology and Rheumatology), Division of Immunology and Rheumatology, Stanford University , Stanford , CA , USA. ^[6] Geriatric Research Education and Clinical [GRECC] Division, VA Palo Alto Health Care System, Palo Alto, CA, USA. ^[7]

关键词 PAD4 RA Rheumatoid arthritis anti-PAD anti-PAD4 autoantibodies citrullination precision medicine protein-arginine deiminase

主题词动物(Animals);关节炎, 类风湿(Arthritis, Rheumatoid);自身抗体(Autoantibodies);人类(Humans);小鼠(Mice)

DOI 10.1080/1744666X.2020.1668778

PMID 31524005

发布时间 2020-06-15

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