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The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant.

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第一作者： Ina,Buchholz

第一单位： Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany; ZIK HIKE, Center for Innovation Competence "Humoral Immune Reactions in Cardiovascular Diseases", University of Greifswald, 17489 Greifswald, Germany.

作者： Ina,Buchholz ^[1] ; Felix,Nagel ^[1] ; Annelie,Klein ^[1] ; Preshit R,Wagh ^[2] ; Ujjwal M,Mahajan ^[3] ; Andreas,Greinacher ^[4] ; Markus M,Lerch ^[2] ; Julia,Mayerle ^[3] ; Mihaela,Delcea ^[5]

作者单位： Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany; ZIK HIKE, Center for Innovation Competence "Humoral Immune Reactions in Cardiovascular Diseases", University of Greifswald, 17489 Greifswald, Germany. ^[1] Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany. ^[2] Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany; Department of Medicine II, Ludwig-Maximilian University of Munich, 81377 Munich, Germany. ^[3] Institute for Immunology and Transfusion Medicine, University Medicine of Greifswald, 17475 Greifswald, Germany. ^[4] Institute of Biochemistry, University of Greifswald, 17489 Greifswald, Germany; ZIK HIKE, Center for Innovation Competence "Humoral Immune Reactions in Cardiovascular Diseases", University of Greifswald, 17489 Greifswald, Germany. Electronic address: delceam@uni-greifswald.de. ^[5]

关键词 Circular dichroism spectroscopy (CD)Pancreatitis Serine protease inhibitor Kazal type 1 (SPINK1)Stress conditions Surface plasmon resonance (SPR)Trypsin inhibitor

医学主题词疾病恶化(Disease Progression);HEK293细胞(HEK293 Cells);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);突变(Mutation);胰腺炎(Pancreatitis);蛋白质构象(Protein Conformation);应激, 生理学(Stress, Physiological);温度(Temperature);胰蛋白酶(Trypsin);胰蛋白酶抑制剂, Kazal胰腺(Trypsin Inhibitor, Kazal Pancreatic)

DOI 10.1016/j.bbapap.2019.140281

PMID 31525466

发布时间 2021-01-10

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Biochimica et biophysica acta. Proteins and proteomics

2020年1868卷1期

140281页

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Biochimica et biophysica acta. Proteins and proteomics

2020年1868卷1期

140281页

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The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant.

Biochimica et biophysica acta. Proteins and proteomics

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The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant.

Biochimica et biophysica acta. Proteins and proteomics

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Biochimica et biophysica acta. Proteins and proteomics

相关期刊

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