Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis.

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作者： Line,Heylen ^[1] ; Bernard,Thienpont ^[2] ; Pieter,Busschaert ^[3] ; Ben,Sprangers ^[4] ; Dirk,Kuypers ^[5] ; Matthieu,Moisse ^[6] ; Evelyne,Lerut ^[7] ; Diether,Lambrechts ^[8] ; Maarten,Naesens ^[5]

作者单位： Department of Nephrology, University Hospitals Leuven, Leuven, Belgium; Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium. ^[1] Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB Leuven, Leuven, Belgium. ^[2] VIB Center for Cancer Biology, VIB Leuven, Leuven, Belgium; Division of Gynecological Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. ^[3] Department of Nephrology, University Hospitals Leuven, Leuven, Belgium; Laboratory of Experimental Transplantation, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium. ^[4] Department of Nephrology, University Hospitals Leuven, Leuven, Belgium; Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium. ^[5] VIB Center for Cancer Biology, VIB Leuven, Leuven, Belgium. ^[6] Department of Pathology, University Hospitals Leuven, Leuven, Belgium. ^[7] Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium; VIB Center for Cancer Biology, VIB Leuven, Leuven, Belgium. Electronic address: diether.lambrechts@kuleuven.vib.be. ^[8]

关键词 DNA methylation ageing chronic allograft injury epigenetics fibrosis kidney transplantation