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首页> Lancet (London, England)> Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial.

Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER): a phase 2, randomised, double-blind, placebo-controlled trial.

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作者： Rajiv,Agarwal ^[1] ; Patrick,Rossignol ^[2] ; Alain,Romero ^[3] ; Dahlia,Garza ^[4] ; Martha R,Mayo ^[4] ; Suzette,Warren ^[4] ; Jia,Ma ^[5] ; William B,White ^[6] ; Bryan,Williams ^[7]

作者单位： Department of Medicine, Division of Nephrology, Indiana University and Richard L Roudebush VA Medical Center, Indianapolis, IN, USA. Electronic address: ragarwal@iu.edu. ^[1] University of Lorraine, Institut National de la Santé et de la Recherche Médicale (Inserm) 1433 CIC-P CHRU de Nancy, Inserm U1116 and French Clinical Research Infrastructure Network INI-CRCT, Nancy, France. ^[2] Medical Affairs, Relypsa, a Vifor Pharma Group Company, Redwood City, CA, USA. ^[3] Clinical Development, Relypsa, a Vifor Pharma Group Company, Redwood City, CA, USA. ^[4] Biometrics, Relypsa, a Vifor Pharma Group Company, Redwood City, CA, USA. ^[5] Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT, USA. ^[6] Institute of Cardiovascular Sciences University College London (UCL) and National Institute for Health Research UCL/UCL Hospitals Biomedical Research Centre, London, UK. ^[7]

主题词成年人(Adult);老年人(Aged);利尿药(Diuretics);双盲法(Double-Blind Method);药物疗法, 联合(Drug Therapy, Combination);女(雌)性(Female);人类(Humans);高钾血症(Hyperkalemia);高血压(Hypertension);男(雄)性(Male);中年人(Middle Aged);聚合物(Polymers);钾(Potassium);肾功能不全, 慢性(Renal Insufficiency, Chronic);螺内酯(Spironolactone);治疗结果(Treatment Outcome)

DOI 10.1016/S0140-6736(19)32135-X

PMID 31533906

发布时间 2022-03-23

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Lancet (London, England)

Lancet (London, England)

2019年394卷10208期

1540-1550页

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