The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing <i>p21</i>.

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第一作者： Keishi,Fukuura

第一单位： Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

作者： Keishi,Fukuura ^[1] ; Yasumichi,Inoue ^[2] ; Chiharu,Miyajima ^[3] ; Shin,Watanabe ^[1] ; Muneshige,Tokugawa ^[1] ; Daisuke,Morishita ^[1] ; Nobumichi,Ohoka ^[4] ; Masayuki,Komada ^[5] ; Hidetoshi,Hayashi ^[6]

作者单位： Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. ^[1] Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan yainoue@phar.nagoya-cu.ac.jp.;Department of Innovative Therapeutics Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. ^[2] Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.;Department of Innovative Therapeutics Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. ^[3] Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, Kawasaki 210-9501, Japan. ^[4] Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8501, Japan.;School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan. ^[5] Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan hhayashi@phar.nagoya-cu.ac.jp.;Department of Innovative Therapeutics Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan. ^[6]

关键词 SET8 USP17 cell cycle deubiquitylation (deubiquitination)histone methylation p21 posttranslational modification (PTM)senescence