Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine.

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第一作者： André,Daher

第一单位： Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com.

作者： André,Daher ^[1] ; Ghait,Aljayyoussi ^[2] ; Dhelio,Pereira ^[3] ; Marcus V G,Lacerda ^[4] ; Márcia A A,Alexandre ^[5] ; Cristiana T,Nascimento ^[6] ; Júlio Castro,Alves ^[7] ; Laís Bastos,da Fonseca ^[8] ; Diego Medeiros Dias,da Silva ^[8] ; Douglas Pereira,Pinto ^[8] ; Danielle Fonseca,Rodrigues ^[9] ; Ana Carolina Rios,Silvino ^[10] ; Taís Nóbrega,de Sousa ^[10] ; Cristiana Ferreira Alves,de Brito ^[10] ; Feiko O,Ter Kuile ^[11] ; David G,Lalloo ^[11]

作者单位： Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com. ^[1] Vice-presidency of Research and Biological Collections, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. andredaher@gmail.com. ^[2] Liverpool School of Tropical Medicine, Liverpool, UK. andredaher@gmail.com. ^[3] Liverpool School of Tropical Medicine, Liverpool, UK. ^[4] Tropical Medicine Research Center of Rondonia (CEPEM), Porto Velho, Rondonia, Brazil. ^[5] Federal University of Rondonia (UNIR), Porto Velho, Rondonia, Brazil. ^[6] Research Institute Leônidas & Maria Deane, FIOCRUZ, Manaus, Brazil. ^[7] Foundation of Tropical Medicine Dr. Heitor Vieira Dourado, Manaus, Brazil. ^[8] National Institute of Infectious Disease, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. ^[9] Laboratory of Pharmacokinetics (SEFAR), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil. ^[10] Institute René Rachou, Oswaldo Cruz Foundation (FIOCRUZ), Belo Horizonte, Brazil. ^[11]

关键词 ACT Anti-malarial treatment Artemisinin-based combination therapy Chloroquine Clinical trial Lumefantrine Malaria Mefloquine Pharmacokinetics Plasmodium vivax Primaquine