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Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

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第一作者： Rhys,Jones

第一单位： Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, Wales, UK.

作者： Rhys,Jones ^[1] ; Marcela Sandoval,Velasco ^[2] ; Llinos G,Harris ^[1] ; Sue,Morgan ^[3] ; Mark,Temple ^[3] ; Michael C,Ruddy ^[4] ; Rhian,Williams ^[5] ; Michael D,Perry ^[5] ; Matt,Hitchings ^[1] ; Thomas S,Wilkinson ^[1] ; Thomas,Humphrey ^[1] ; M Thomas P,Gilbert ^[6] ; Angharad P,Davies ^[7]

作者单位： Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, Wales, UK. ^[1] Natural History Museum of Denmark, University of Copenhagen, Copenhagen K, Denmark. ^[2] Health Protection Division (Mid and West Wales), Public Health Wales, Swansea, Wales, UK. ^[3] Wales Centre for Mycobacteriology, Llandough Hospital, Cardiff, Wales, UK; Public Health Wales Microbiology, Swansea, Wales, UK. ^[4] Wales Centre for Mycobacteriology, Llandough Hospital, Cardiff, Wales, UK. ^[5] Natural History Museum of Denmark, University of Copenhagen, Copenhagen K, Denmark; Norwegian University of Science and Technology, University Museum, Trondheim, Norway. ^[6] Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, Wales, UK; Public Health Wales Microbiology, Swansea, Wales, UK. Electronic address: angharad.p.davies@swansea.ac.uk. ^[7]

关键词 Ancient DNA library construction Mycobacterium tuberculosis Outbreak investigation Palaeogenomics Whole genome sequencing