Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.
作者:
Pierre-Francois,Laterre [1]
;
Scott M,Berry [2]
;
Allan,Blemings [3]
;
Jan E,Carlsen [4]
;
Bruno,François [5]
;
Todd,Graves [2]
;
Karsten,Jacobsen [3]
;
Roger J,Lewis [2]
;
Steven M,Opal [6]
;
Anders,Perner [7]
;
Peter,Pickkers [8]
;
James A,Russell [9]
;
Nis A,Windeløv [10]
;
Donald M,Yealy [11]
;
Pierre,Asfar [12]
;
Morten H,Bestle [3]
;
Grégoire,Muller [13]
;
Cédric,Bruel [14]
;
Noëlle,Brulé [15]
;
Johan,Decruyenaere [16]
;
Alain-Michel,Dive [17]
;
Thierry,Dugernier [18]
;
Kenneth,Krell [19]
;
Jean-Yves,Lefrant [20]
;
Bruno,Megarbane [21]
;
Emmanuelle,Mercier [22]
;
Jean-Paul,Mira [23]
;
Jean-Pierre,Quenot [24]
;
Bodil Steen,Rasmussen [25]
;
Hans-Christian,Thorsen-Meyer [26]
;
Margot,Vander Laenen [27]
;
Marianne Lauridsen,Vang [28]
;
Philippe,Vignon [10]
;
Isabelle,Vinatier [29]
;
Sine,Wichmann [30]
;
Xavier,Wittebole [5]
;
Anne Louise,Kjølbye [31]
;
Derek C,Angus [32]
;
SEPSIS-ACT Investigators [1]
作者单位:
Department of Critical Care Medicine, St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
[1]
Berry Consultants LLC, Austin, Texas.
[2]
Ferring Pharmaceuticals A/S, Copenhagen, Denmark.
[3]
StraDevo A/S, Kongens Lyngby, Denmark.
[4]
Medical-Surgical Intensive Care Unit, Inserm CIC1435, Dupuytren Teaching Hospital, Limoges, France.
[5]
Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California.
[6]
Los Angeles Biomedical Research Institute, Torrance, California.
[7]
Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
[8]
Division of Infectious Diseases, Alpert Medical School of Brown University, Providence, Rhode Island.
[9]
Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark.
[10]
Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
[11]
Center for Heart Lung Innovation and the Division of Critical Care Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
[12]
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[13]
Centre Hospitalier Universitaire d'Angers, Angers, France.
[14]
Nordsjaellands Hospital in Hilleroed, Copenhagen, Denmark.
[15]
Centre Hospitalier Régional, Hopital de La Source, Orléans, France.
[16]
Fondation Hôpital Saint Joseph. Paris, France.
[17]
Medical Intensive Care Unit, Nantes University Hospital, Nantes, France.
[18]
Ghent University Hospital, Ghent, Belgium.
[19]
CHU UCL Manur, Mont-Godinne, Yvoir, Belgium.
[20]
Clinique Saint-Pierre, Ottignies, Belgium.
[21]
Eastern Idaho Regional Medical Center, Idaho Falls.
[22]
Centre Hospitalier Universitaire de Nîmes, Nîmes, France.
[23]
Lariboisière Hospital, Paris-Diderot University, INSERM UMRS-1144, Paris, France.
[24]
Centre Hospitalier Régional et Universitaire de Tours, Tours, France.
[25]
Hopital Cochin, Paris, France.
[26]
Centre Hospitalier Régional et Universitaire de Dijon, Dijon, France.
[27]
Aalborg Universitetshospital, Aalborg, Denmark.
[28]
Ziekenhuis Oost-Limburg, Genk, Belgium.
[29]
Randers Regions Hospital, Randers, Denmark.
[30]
Centre Hospitalier Departemental de Vendee, La Roche sur Yon, France.
[31]
Bispebjerg Hospital, Copenhagen, Denmark.
[32]
Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care, University of Pittsburgh, Pittsburgh, Pennsylvania.
[33]
Associate Editor, JAMA.
[34]
DOI
10.1001/jama.2019.14607
PMID
31577035
发布时间
2022-04-22
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JAMA
JAMA
1476-1485页
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