Synthesis, PASS predication, in vitro antimicrobial evaluation and pharmacokinetic study of novel n-octyl glucopyranoside esters.

导出 LinkOut

翻译打印收藏纠错

作者： Mohammed M,Matin ^[1] ; Sreebash C,Bhattacharjee ^[2] ; Priyanka,Chakraborty ^[3] ; Muhammad S,Alam ^[4]

作者单位： Organic Research Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chattogram, 4331, Bangladesh. Electronic address: mahbubchem@cu.ac.bd. ^[1] Organic Research Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chattogram, 4331, Bangladesh; Chemical Research Division, Bangladesh Council of Scientific & Industrial Research (BCSIR) Laboratories, Chattogram, 4220, Bangladesh. ^[2] Organic Research Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chattogram, 4331, Bangladesh. ^[3] Molecular Modeling and Drug Design Laboratory, Bangladesh Council of Scientific & Industrial Research (BCSIR) Laboratories, Chattogram, 4220, Bangladesh. ^[4]

关键词 AdmetSAR Antimicrobial activities Molecular docking PASS predication Regioselective acylation SwissADME n-Octyl β-d-glucopyranoside (OBG)

主题词抗感染药(Anti-Infective Agents);酯类(Esters);葡糖苷类(Glucosides);蛋白质构象(Protein Conformation);类固醇14-脱甲基酶(Sterol 14-Demethylase);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.carres.2019.107812

PMID 31585251

发布时间 2020-02-24

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交