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Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk.

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第一作者： William S,Kremen

第一单位： Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA. Electronic address: wkremen@ucsd.edu.

作者： William S,Kremen ^[1] ; Matthew S,Panizzon ^[2] ; Jeremy A,Elman ^[2] ; Eric L,Granholm ^[3] ; Ole A,Andreassen ^[4] ; Anders M,Dale ^[5] ; Nathan A,Gillespie ^[6] ; Daniel E,Gustavson ^[2] ; Mark W,Logue ^[7] ; Michael J,Lyons ^[8] ; Michael C,Neale ^[6] ; Chandra A,Reynolds ^[9] ; Nathan,Whitsel ^[2] ; Carol E,Franz ^[2]

作者单位： Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA. Electronic address: wkremen@ucsd.edu. ^[1] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA. ^[2] Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Psychology Service, VA San Diego Healthcare System, La Jolla, CA, USA. ^[3] NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. ^[4] Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Department of Radiology, University of California, San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. ^[5] Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA. ^[6] National Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry and Biomedical Genetics Section, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. ^[7] Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA. ^[8] Department of Psychology, University of California, Riverside, Riverside, CA, USA. ^[9]

关键词 Biomarker Early identification Locus coeruleus Mild cognitive impairment Polygenic risk score Risk indicator