Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.

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作者： Tadashi,Ashizawa ^[1] ; Akira,Iizuka ^[1] ; Chie,Maeda ^[1] ; Emiko,Tanaka ^[1] ; Ryota,Kondou ^[1] ; Haruo,Miyata ^[1] ; Takashi,Sugino ^[2] ; Takuya,Kawata ^[2] ; Shoichi,Deguchi ^[3] ; Koichi,Mitsuya ^[3] ; Nakamasa,Hayashi ^[3] ; Akira,Asai ^[4] ; Mamoru,Ito ^[5] ; Ken,Yamaguchi ^[6] ; Yasuto,Akiyama ^[7]

作者单位： Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. ^[1] Division of Pathology, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. ^[2] Division of Neurosurgery, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. ^[3] Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan. ^[4] Research Division, Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan. ^[5] Office of the president, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. ^[6] Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Electronic address: y.akiyama@scchr.jp. ^[7]

关键词 Exhaustion marker Humanized NOG-MHC dKO mouse STAT3 inhibitor T cell exhaustion Tumor-infiltrating lymphocytes