首页> European journal of medicinal chemistry> Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.

Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.

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第一作者： Martyna Z,Wróbel

第一单位： Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland. Electronic address: martyna.wrobel@wum.edu.pl.

作者： Martyna Z,Wróbel ^[1] ; Andrzej,Chodkowski ^[2] ; Franciszek,Herold ^[2] ; Monika,Marciniak ^[2] ; Maciej,Dawidowski ^[2] ; Agata,Siwek ^[3] ; Gabriela,Starowicz ^[3] ; Katarzyna,Stachowicz ^[4] ; Bernadeta,Szewczyk ^[4] ; Gabriel,Nowak ^[5] ; Mariusz,Belka ^[6] ; Tomasz,Bączek ^[6] ; Grzegorz,Satała ^[7] ; Andrzej J,Bojarski ^[7] ; Jadwiga,Turło ^[2]

作者单位： Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland. Electronic address: martyna.wrobel@wum.edu.pl. ^[1] Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland. ^[2] Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland. ^[3] Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland. ^[4] Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland. ^[5] Department of Pharmaceutical Chemistry, Medical University of Gdańsk, 80-416, Gdańsk, Poland. ^[6] Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland. ^[7]

关键词 5-HT(1A) agonists 5-HT(1A)/SERT dual activity Antidepressants D(2) receptor ligands Multitarget directed ligand Serotonin reuptake inhibitors