Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.

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第一作者： Surya,Nagaraja

第一单位： Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

作者： Surya,Nagaraja ^[1] ; Michael A,Quezada ^[2] ; Shawn M,Gillespie ^[2] ; Marlene,Arzt ^[2] ; James J,Lennon ^[2] ; Pamelyn J,Woo ^[2] ; Volker,Hovestadt ^[3] ; Madhuri,Kambhampati ^[4] ; Mariella G,Filbin ^[5] ; Mario L,Suva ^[3] ; Javad,Nazarian ^[6] ; Michelle,Monje ^[7]

作者单位： Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. ^[1] Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA. ^[2] Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[3] Research Center for Genetic Medicine, Children's National Health System, Washington, DC, USA. ^[4] Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA, USA. ^[5] Research Center for Genetic Medicine, Children's National Health System, Washington, DC, USA; Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Oncology, University Children's Hospital, Zurich, Switzerland. ^[6] Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mmonje@stanford.edu. ^[7]

关键词 DIPG H3.3 H3K27Ac H3K27M H3K27me3 PRC2 active enhancers glioma histone variant oligodendrocyte precursor cell