ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors.

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第一作者： Katja,Kaipio

第一单位： Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.

作者： Katja,Kaipio ^[1] ; Ping,Chen ^[2] ; Pia,Roering ^[1] ; Kaisa,Huhtinen ^[1] ; Piia,Mikkonen ^[3] ; Päivi,Östling ^[4] ; Laura,Lehtinen ^[1] ; Naziha,Mansuri ^[1] ; Taina,Korpela ^[1] ; Swapnil,Potdar ^[5] ; Johanna,Hynninen ^[6] ; Annika,Auranen ^[7] ; Seija,Grénman ^[6] ; Krister,Wennerberg ^[8] ; Sampsa,Hautaniemi ^[9] ; Olli,Carpén ^[10]

作者单位： Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland. ^[1] Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institutet, Huddinge, Sweden. ^[2] Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland. ^[3] Science for Life Laboratory Department of Oncology & Pathology, Karolinska Institutet, Huddinge, Sweden.;Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland. ^[4] Institute for Molecular Medicine Finland, High Throughput Biomedicine Unit (HTB), University of Helsinki, Helsinki, Finland. ^[5] Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, Turku, Finland. ^[6] Department of Obstetrics and Gynaecology, University of Tampere and Tampere University Hospital, Tampere, Finland. ^[7] Institute for Molecular Medicine Finland, High Throughput Biomedicine Unit (HTB), University of Helsinki, Helsinki, Finland.;Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. ^[8] Research Programs Unit, Genome-Scale Biology and Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland. ^[9] Research Center for Cancer, Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland.;Research Programs Unit, Genome-Scale Biology and Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland. ^[10]

关键词 drug sensitivity ovarian cancer patient-derived cell line stem-like cell survival