首页> The Journal of biological chemistry> 5-Formylcytosine-induced DNA-peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells.

5-Formylcytosine-induced DNA-peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells.

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第一作者： Shaofei,Ji

第一单位： Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.

作者： Shaofei,Ji ^[1] ; Daeyoon,Park ^[2] ; Konstantin,Kropachev ^[3] ; Marina,Kolbanovskiy ^[3] ; Iwen,Fu ^[4] ; Suse,Broyde ^[4] ; Maram,Essawy ^[5] ; Nicholas E,Geacintov ^[3] ; Natalia Y,Tretyakova ^[6]

作者单位： Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455. ^[1] Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455. ^[2] Department of Chemistry, New York University, New York, New York 10003. ^[3] Department of Biology, New York University, New York, New York 10003. ^[4] Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455. ^[5] Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455. Electronic address: trety001@umn.edu. ^[6]

关键词 5-formylcytosine DNA damage DNA transcription DNA–peptide cross-link RNA polymerase II bulky DNA lesion epigenetic mark epigenetics gene regulation human cells nucleotide excision repair protein cross-linking transcription