Identification of Cancer-associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism.

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作者： Ziwei,Dai ^[1] ; Shiyu,Yang ^[2] ; Liyan,Xu ^[2] ; Hongrong,Hu ^[2] ; Kun,Liao ^[2] ; Jianghuang,Wang ^[2] ; Qian,Wang ^[3] ; Shuaishi,Gao ^[1] ; Bo,Li ^[4] ; Luhua,Lai ^[5]

作者单位： Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. ^[1] Program of Cancer Research, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. ^[2] Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. ^[3] Program of Cancer Research, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. libo47@mail.sysu.edu.cn. ^[4] Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. lhlai@pku.edu.cn. ^[5] Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. lhlai@pku.edu.cn. ^[6] Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, 100871, China. lhlai@pku.edu.cn. ^[7]

关键词 Cancer metabolism Drug discovery Flux balance analysis Genome-scale metabolic model Pareto optimality

主题词细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);人类(Humans);代谢疾病(Metabolic Diseases);模型, 生物学(Models, Biological);肿瘤(Neoplasms)

DOI 10.1186/s12964-019-0439-y

PMID 31601242

发布时间 2020-07-13

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