Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions.-论文-万方医学网

第一作者： Zhongwen,Li

第一单位： Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China.

作者： Zhongwen,Li ^[1] ; Jun,Wu ^[2] ; Lei,Wang ^[3] ; Weifang,Han ^[4] ; Juan,Yu ^[2] ; Xin,Liu ^[3] ; Yukai,Wang ^[4] ; Ying,Zhang ^[2] ; Guihai,Feng ^[3] ; Wei,Li ^[4] ; Glyn Nigel,Stacey ^[2] ; Qi,Gu ^[3] ; Baoyang,Hu ^[4] ; Liu,Wang ^[1] ; Qi,Zhou ^[2] ; Jie,Hao ^[3]

作者单位： Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. ^[1] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ^[2] Beijing Stem Cell Bank, Chinese Academy of Sciences, Beijing, 100190, China. ^[3] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ^[4] University of Chinese Academy of Sciences, Beijing, 100049, China. ^[5] International Stem Cell Banking Initiative, Hertfordshire, UK. ^[6] State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ^[7] Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, China. zhouqi@ioz.ac.cn. ^[8] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. zhouqi@ioz.ac.cn. ^[9] Beijing Stem Cell Bank, Chinese Academy of Sciences, Beijing, 100190, China. zhouqi@ioz.ac.cn. ^[10] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhouqi@ioz.ac.cn. ^[11] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. haojie@ioz.ac.cn. ^[12] Beijing Stem Cell Bank, Chinese Academy of Sciences, Beijing, 100190, China. haojie@ioz.ac.cn. ^[13] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. haojie@ioz.ac.cn. ^[14]

主题词激活素类(Activins);动物(Animals);细胞培养技术(Cell Culture Techniques);细胞分化(Cell Differentiation);培养基(Culture Media);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA结合蛋白质类(DNA-Binding Proteins);内胚层(Endoderm);基因表达调控, 发育期(Gene Expression Regulation, Developmental);肝细胞(Hepatocytes);人类(Humans);白细胞介素受体公共γ亚单位(Interleukin Receptor Common gamma Subunit);肝(Liver);肝功能衰竭(Liver Failure);肝再生(Liver Regeneration);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);多基因族(Multigene Family);吡啶类(Pyridines);嘧啶类(Pyrimidines);干细胞移植(Stem Cell Transplantation)

DOI 10.1038/s41419-019-1967-5

PMID 31601782

发布时间 2021-01-10

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Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions.

Cell death & disease

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Cell death & disease

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Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions.

Cell death & disease

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Cell death & disease

相关期刊

检索历史清除