首页> Molecular therapy : the journal of the American Society of Gene Therapy> dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

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第一作者： Gaia,Colasante

第一单位： Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: colasante.gaia@hsr.it.

作者： Gaia,Colasante ^[1] ; Gabriele,Lignani ^[2] ; Simone,Brusco ^[3] ; Claudia,Di Berardino ^[3] ; Jenna,Carpenter ^[2] ; Serena,Giannelli ^[3] ; Nicholas,Valassina ^[3] ; Simone,Bido ^[3] ; Raffaele,Ricci ^[3] ; Valerio,Castoldi ^[4] ; Silvia,Marenna ^[4] ; Timothy,Church ^[2] ; Luca,Massimino ^[3] ; Giuseppe,Morabito ^[3] ; Fabio,Benfenati ^[5] ; Stephanie,Schorge ^[2] ; Letizia,Leocani ^[4] ; Dimitri M,Kullmann ^[2] ; Vania,Broccoli ^[6]

作者单位： Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy. Electronic address: colasante.gaia@hsr.it. ^[1] Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. ^[2] Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy. ^[3] Experimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, 20132 Milan, Italy. ^[4] Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, 16132 Genova, Italy; IRCCS Ospedale Policlinico San Martino, University of Genova, 16132 Genova, Italy. ^[5] Stem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy; CNR Institute of Neuroscience, 20129 Milan, Italy. Electronic address: broccoli.vania@hsr.it. ^[6]

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