Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

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作者： Chen-Chung,Lin ^[1] ; Brandon F,Law ^[1] ; Justin M,Hettick ^[1]

作者单位： Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia. ^[1]

关键词 4,4′-methylene diphenyl diisocyanate (MDI)PPP3CA calcineurin/NFAT signaling diisocyanates (dNCOs)iNOS occupational asthma (OA)

主题词动物(Animals);抗原(Antigens);钙神经素(Calcineurin);减量调节(Down-Regulation);女(雌)性(Female);异氰酸盐类(Isocyanates);白细胞计数(Leukocyte Count);巨噬细胞(Macrophages);小鼠(Mice);微RNAs(MicroRNAs);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);职业暴露(Occupational Exposure)

DOI 10.1093/toxsci/kfz215

PMID 31609387

发布时间 2021-05-27

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Toxicological sciences

2020年173卷1期

100-113页

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Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

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Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

Toxicological sciences

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Toxicological sciences

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