The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.

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第一作者： Teresa,Vezza

第一单位： CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.

作者： Teresa,Vezza ^[1] ; Alba,Rodríguez-Nogales ^[2] ; Francesca,Algieri ^[3] ; José,Garrido-Mesa ^[3] ; Miguel,Romero ^[4] ; Manuel,Sánchez ^[4] ; Marta,Toral ^[5] ; Beatriz,Martín-García ^[6] ; Ana M,Gómez-Caravaca ^[6] ; David,Arráez-Román ^[6] ; Antonio,Segura-Carretero ^[6] ; Vicente,Micol ^[7] ; Federico,García ^[8] ; María Pilar,Utrilla ^[1] ; Juan,Duarte ^[4] ; María Elena,Rodríguez-Cabezas ^[1] ; Julio,Gálvez ^[1]

作者单位： CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. ^[1] Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. Electronic address: albarnogales@gmail.com. ^[2] CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain. ^[3] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain; CIBER-Enfermedades Cardiovasculares, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, 18071, Granada, Spain. ^[4] Gene Regulation in Cardiovascular Remodeling and Inflammation Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. ^[5] Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071, Granada, Spain; Research and Development Centre for Functional Food (CIDAF), PTS Granada, 18016, Granada, Spain. ^[6] CIBERobn, Instituto de Salud Carlos III (CB12/03/30038), Institute of Molecular and Cell Biology (IMCB), Miguel Hernández University (UMH), 03202, Elche, Alicante, Spain. ^[7] Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain; Clinical Microbiology Service, Hospital Universitario San Cecilio, Red de Investigación en SIDA, Granada, Spain. ^[8]

关键词 Diet induced obesity Gut microbiota Inflammation Mice Oleuropein Olive leaf extract Vascular dysfunction