Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases.

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作者： Isabella,Lupi ^[1] ; Alessandro,Brancatella ^[1] ; Mirco,Cosottini ^[2] ; Nicola,Viola ^[1] ; Giulia,Lanzolla ^[1] ; Daniele,Sgrò ^[1] ; Giulia Di,Dalmazi ^[3] ; Francesco,Latrofa ^[1] ; Patrizio,Caturegli ^[4] ; Claudio,Marcocci ^[1]

作者单位： Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. ^[1] Neuroradiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. ^[2] Section of Endocrinology, Department of Medicine and Aging Sciences, Ce.S.I-Me.T., "G.D'Annunzio" University of Chieti-Pescara, Chieti, Italy. ^[3] Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore Maryland, USA. ^[4]

关键词 2019 ACTH Adenocarcinoma Adult Asthenia Atezolizumab*Autoimmune disorders Autoimmune hypophysitis CT scan Cortisol Diabetes mellitus type 1 Diabetic ketoacidosis FSH Fatigue Female Fludrocortisone Glucocorticoids Glucose (blood)Gonadotrophins Gonadotropins HLA genotyping Headache Hydrocortisone Hyperglycaemia Hypergonadotropic hypogonadism Hyperkalaemia Hypoadrenalism Hypogonadism Hyponatraemia Hypophysitis Hypothyroidism Immune checkpoint inhibitors*Immunology Indirect immunofluorescence*Insight into disease pathogenesis or mechanism of therapy Insulin Ipilimumab Italy LH Levothyroxine Male Metastatic melanoma Mineralocorticoids Myasthaenia Nausea Nivolumab Non-small cell lung cancer*October Oestradiol (E2)Oncology Pembrolizumab*Pituitary Pituitary function Potassium Pyrexia Renin (blood)Sodium TSH Testosterone Thyroid antibodies Thyrotoxicosis Vitiligo Vomiting White

DOI 10.1530/EDM-19-0102

PMID 31610523

发布时间 2024-02-27

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Endocrinology, diabetes & metabolism case reports

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Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases.

Endocrinology, diabetes & metabolism case reports

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Endocrinology, diabetes & metabolism case reports

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Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases.

Endocrinology, diabetes & metabolism case reports

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Endocrinology, diabetes & metabolism case reports

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