Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity.

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作者： Wooseong,Kim ^[1] ; Hanju,Lee ^[1] ; Soojin,Kim ^[1] ; Sanghyun,Joo ^[1] ; Seongkeun,Jeong ^[1] ; Jin-Wook,Yoo ^[1] ; Yunjin,Jung ^[2]

作者单位： College of Pharmacy, Pusan National University, Busan, Republic of Korea. ^[1] College of Pharmacy, Pusan National University, Busan, Republic of Korea. Electronic address: jungy@pusan.ac.kr. ^[2]

关键词 Chalcone Colitis Electrophile Michael acceptor Nrf2 Sofalcone

主题词动物(Animals);查耳酮类(Chalcones);结肠炎(Colitis);胃肠道(Gastrointestinal Tract);男(雄)性(Male);NF-E2相关因子2(NF-E2-Related Factor 2);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.ejphar.2019.172722

PMID 31614142

发布时间 2020-04-22

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European journal of pharmacology

2019年865卷

172722页

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Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity.

European journal of pharmacology

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European journal of pharmacology

相关期刊

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Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity.

European journal of pharmacology

相似文献

European journal of pharmacology

相关期刊

检索历史清除