Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness.

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第一作者： Daniela,Bermudez

第一单位： Laboratorio de Fisiología Comparada, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.

作者： Daniela,Bermudez ^[1] ; Priti,Azad ^[2] ; Rómulo,Figueroa-Mujíca ^[1] ; Gustavo,Vizcardo-Galindo ^[1] ; Noemí,Corante ^[1] ; Cristina,Guerra-Giraldez ^[3] ; Gabriel G,Haddad ^[4] ; Francisco C,Villafuerte ^[5]

作者单位： Laboratorio de Fisiología Comparada, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. ^[1] Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, California. ^[2] Laboratorio de Inflamación Cerebral, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. ^[3] Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, California.;Department of Neurosciences, University of California San Diego, La Jolla, California.;Rady Children's Hospital, San Diego, La Jolla, California. ^[4] Laboratorio de Fisiología Comparada, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.;Instituto de Investigaciones de la Altura (IIA), Universidad Peruana Cayetano Heredia, Lima, Peru. ^[5]

关键词 Andean chronic mountain sickness erythropoiesis excessive erythrocytosis high altitude

主题词高海拔(Altitude);高原病(Altitude Sickness);慢性病(Chronic Disease);红系前体细胞(Erythroid Precursor Cells);红细胞生成素(Erythropoietin);基因表达调控(Gene Expression Regulation);疾病遗传易感性(Genetic Predisposition to Disease);内环境稳定(Homeostasis);人类(Humans);铁(Iron);白细胞, 单核(Leukocytes, Mononuclear);氧(Oxygen)

DOI 10.1152/ajpregu.00250.2019

PMID 31617751

发布时间 2024-04-22

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American journal of physiology. Regulatory, integrative and comparative physiology

2020年318卷1期

R49-R56页

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Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness.

American journal of physiology. Regulatory, integrative and comparative physiology

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American journal of physiology. Regulatory, integrative and comparative physiology

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Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness.

American journal of physiology. Regulatory, integrative and comparative physiology

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American journal of physiology. Regulatory, integrative and comparative physiology

相关期刊

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