BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.-论文-万方医学网

作者： Arun,Kanakkanthara ^[1] ; Kiran,Kurmi ^[2] ; Thomas L,Ekstrom ^[2] ; Xiaonan,Hou ^[1] ; Emma R,Purfeerst ^[1] ; Ethan P,Heinzen ^[1] ; Cristina,Correia ^[3] ; Catherine J,Huntoon ^[1] ; Daniel,O'Brien ^[1] ; Andrea E,Wahner Hendrickson ^[3] ; Sean C,Dowdy ^[1] ; Hu,Li ^[4] ; Ann L,Oberg ^[2] ; Taro,Hitosugi ^[3] ; Scott H,Kaufmann ^[1] ; S John,Weroha ^[2] ; Larry M,Karnitz ^[1]

作者单位： Department of Oncology, Mayo Clinic, Rochester, Minnesota. ^[1] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. ^[2] Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota. ^[3] Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota. ^[4] Department of Oncology, Mayo Clinic, Rochester, Minnesota. karnitz.larry@mayo.edu. ^[5]

主题词动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);BRCA1蛋白质(BRCA1 Protein);细胞系, 肿瘤(Cell Line, Tumor);细胞周期蛋白质依赖激酶类(Cyclin-Dependent Kinases);DNA甲基化(DNA Methylation);能量代谢(Energy Metabolism);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);腙类(Hydrazones);小鼠(Mice);线粒体(Mitochondria);突变(Mutation);烟酰胺N-甲基转移酶(Nicotinamide N-Methyltransferase);卵巢肿瘤(Ovarian Neoplasms);卵巢(Ovary);氧化磷酸化(Oxidative Phosphorylation);启动区, 遗传(Promoter Regions, Genetic);三唑类(Triazoles);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/0008-5472.CAN-19-1405

PMID 31619387

发布时间 2020-06-01

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BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.

Cancer research

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Cancer research

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BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents.

Cancer research

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Cancer research

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