Obesity-linked suppression of membrane-bound <i>O</i>-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

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第一作者： Robert N,Helsley

第一单位： Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States.;Department of Internal Medicine, University of Cincinnati, Cincinnati, United States.

作者： Robert N,Helsley ^[1] ; Venkateshwari,Varadharajan ^[2] ; Amanda L,Brown ^[2] ; Anthony D,Gromovsky ^[2] ; Rebecca C,Schugar ^[2] ; Iyappan,Ramachandiran ^[2] ; Kevin,Fung ^[2] ; Mohammad Nasser,Kabbany ^[2] ; Rakhee,Banerjee ^[2] ; Chase K,Neumann ^[2] ; Chelsea,Finney ^[2] ; Preeti,Pathak ^[2] ; Danny,Orabi ^[2] ; Lucas J,Osborn ^[2] ; William,Massey ^[2] ; Renliang,Zhang ^[2] ; Anagha,Kadam ^[2] ; Brian E,Sansbury ^[3] ; Calvin,Pan ^[4] ; Jessica,Sacks ^[5] ; Richard G,Lee ^[6] ; Rosanne M,Crooke ^[6] ; Mark J,Graham ^[6] ; Madeleine E,Lemieux ^[7] ; Valentin,Gogonea ^[8] ; John P,Kirwan ^[5] ; Daniela S,Allende ^[9] ; Mete,Civelek ^[10] ; Paul L,Fox ^[2] ; Lawrence L,Rudel ^[11] ; Aldons J,Lusis ^[4] ; Matthew,Spite ^[3] ; J Mark,Brown ^[2]

作者单位： Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States.;Department of Internal Medicine, University of Cincinnati, Cincinnati, United States. ^[1] Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, United States. ^[2] Center for Experimental Therapeutics & Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, United States. ^[3] Department of Medicine, University of California, Los Angeles, Los Angeles, United States.;Department of Microbiology, University of California, Los Angeles, Los Angeles, United States.;Department of Human Genetics, University of California, Los Angeles, Los Angeles, United States. ^[4] Department of Pathobiology, Cleveland Clinic, Cleveland, United States. ^[5] Cardiovascular Group, Antisense Drug Discovery, Ionis Pharmaceuticals, Inc, Carlsbad, United States. ^[6] Bioinfo, Plantagenet, Canada. ^[7] Department of Chemistry, Cleveland State University, Cleveland, United States. ^[8] Department of Anatomical Pathology, Cleveland Clinic, Cleveland, United States. ^[9] Department of Biomedical Engineering, University of Virginia, Charlottesville, United States. ^[10] Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, United States. ^[11]

关键词 NAFLD hepatology human biology medicine mouse triacylglycerol