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Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.

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第一作者： Cezary,Ciszewski

第一单位： Department of Medicine, University of Chicago, Chicago, Illinois.

作者： Cezary,Ciszewski ^[1] ; Valentina,Discepolo ^[1] ; Alain,Pacis ^[2] ; Nick,Doerr ^[3] ; Olivier,Tastet ^[2] ; Toufic,Mayassi ^[4] ; Mariantonia,Maglio ^[5] ; Asjad,Basheer ^[3] ; Laith Q,Al-Mawsawi ^[3] ; Peter H R,Green ^[6] ; Renata,Auricchio ^[5] ; Riccardo,Troncone ^[5] ; Thomas A,Waldmann ^[7] ; Nazli,Azimi ^[3] ; Yutaka,Tagaya ^[8] ; Luis B,Barreiro ^[9] ; Bana,Jabri ^[10]

作者单位： Department of Medicine, University of Chicago, Chicago, Illinois. ^[1] Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada. ^[2] Bioniz Therapeutics, Inc., Irvine, California. ^[3] Department of Medicine, University of Chicago, Chicago, Illinois; Committee on Immunology, University of Chicago, Chicago, Illinois. ^[4] Department of Translational Medical Science and European Laboratory for the Investigation of Food Induced Diseases (ELFID), Università degli Studi di Napoli Federico II, Napoli, Italy. ^[5] Celiac Disease Center, Columbia University, New York, New York. ^[6] Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, Maryland. ^[7] Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland. ^[8] Department of Medicine, University of Chicago, Chicago, Illinois; Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois. ^[9] Department of Medicine, University of Chicago, Chicago, Illinois; Committee on Immunology, University of Chicago, Chicago, Illinois; Department of Pathology and Pediatrics, University of Chicago, Chicago, Illinois. Electronic address: bjabri@bsd.uchicago.edu. ^[10]

关键词 Autoimmunity Immune Response Signal Transduction Treatment