The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb.

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作者： Dominika,Rittler ^[1] ; Marcell,Baranyi ^[2] ; Eszter,Molnár ^[3] ; Tamás,Garay ^[4] ; István,Jalsovszky ^[5] ; Imre Károly,Varga ^[6] ; Luca,Hegedűs ^[7] ; Clemens,Aigner ^[8] ; József,Tóvári ^[9] ; József,Tímár ^[10] ; Balázs,Hegedűs ^[11]

作者单位： Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. rittlerdomi@gmail.com. ^[1] Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. baranyi2marci@gmail.com. ^[2] Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. m.molnareszter@gmail.com. ^[3] Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. garayt@gmail.com. ^[4] Pázmány Péter Catholic University, Faculty of Information Technology and Bionics, H-1083 Budapest, Hungary. garayt@gmail.com. ^[5] Oncology Center, Semmelweis University, H-1091 Budapest, Hungary. garayt@gmail.com. ^[6] Eötvös Loránd University, Faculty of Science, Institute of Chemistry, Department of Organic Chemistry; H-1117 Budapest, Hungary. jalso@caesar.elte.hu. ^[7] Eötvös Loránd University, Faculty of Science, Institute of Chemistry, Department of Organic Chemistry; H-1117 Budapest, Hungary. vukracs@caesar.elte.hu. ^[8] Department of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, D-45239 Essen, Germany. luca.hegedues@rlk.uk-essen.de. ^[9] Department of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, D-45239 Essen, Germany. clemens.aigner@ruhrlandklinik.uk-essen.de. ^[10] Department of Experimental Pharmacology, National Institute of Oncology, H-1122 Budapest, Hungary. jtovari@yahoo.com. ^[11] Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. jtimar@gmail.com. ^[12] Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary. balazs.hegedues@rlk.uk-essen.de. ^[13] Department of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, D-45239 Essen, Germany. balazs.hegedues@rlk.uk-essen.de. ^[14]

关键词 Rheb lipophilic bisphosphonate melanoma prenylation inhibition