The 11β-hydroxyandrostenedione pathway and C11-oxy C<sub>21</sub> backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone.

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作者： Therina,du Toit ^[1] ; Amanda C,Swart ^[2]

作者单位： Department of Biochemistry, Stellenbosch University, Stellenbosch, 7600, South Africa. ^[1] Department of Biochemistry, Stellenbosch University, Stellenbosch, 7600, South Africa. Electronic address: acswart@sun.ac.za. ^[2]

关键词 11keto-dihydroprogesterone (11KDHPROG, 11KDHP4, 5α-pregnan-3,11,20-trione)11keto-dihydrotestosterone (11KDHT, 5α-androstan-17β-ol-3,11-dione)Adrenal steroid precursors Castration resistant prostate cancer (CRPC)Cytochrome P450 17α-hydroxylase/17,20 lyase (CYP17A1, P450 c17)UPC(2)-MS/MS (Ultra-performance convergence chromatography tandem mass spectrometry)

主题词雄烯二酮(Androstenedione);细胞, 培养的(Cells, Cultured);人类(Humans);男(雄)性(Male);代谢网络和途径(Metabolic Networks and Pathways);孕酮(Progesterone);前列腺增生(Prostatic Hyperplasia);甾类(Steroids);睾酮(Testosterone)

DOI 10.1016/j.jsbmb.2019.105497

PMID 31626910

发布时间 2020-06-30

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The Journal of steroid biochemistry and molecular biology

2020年196卷

105497页

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The 11β-hydroxyandrostenedione pathway and C11-oxy C<sub>21</sub> backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone.

The Journal of steroid biochemistry and molecular biology

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The Journal of steroid biochemistry and molecular biology

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The 11β-hydroxyandrostenedione pathway and C11-oxy C<sub>21</sub> backdoor pathway are active in benign prostatic hyperplasia yielding 11keto-testosterone and 11keto-progesterone.

The Journal of steroid biochemistry and molecular biology

相似文献

The Journal of steroid biochemistry and molecular biology

相关期刊

检索历史清除