首页> Clinical genitourinary cancer> Pharmacokinetic/Pharmacodynamic Relationship of Enzalutamide and Its Active Metabolite N-Desmethyl Enzalutamide in Metastatic Castration-Resistant Prostate Cancer Patients.

Pharmacokinetic/Pharmacodynamic Relationship of Enzalutamide and Its Active Metabolite N-Desmethyl Enzalutamide in Metastatic Castration-Resistant Prostate Cancer Patients.

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第一作者： Marie-Liesse,Joulia

第一单位： Department of Medical Oncology, Cochin Hospital, Paris Descartes University, CARPEM, AP-HP, Paris, France. Electronic address: joulia.marie@gmail.com.

作者： Marie-Liesse,Joulia ^[1] ; Edith,Carton ^[2] ; Anne,Jouinot ^[2] ; Marie,Allard ^[3] ; Olivier,Huillard ^[2] ; Nihel,Khoudour ^[3] ; Michaël,Peyromaure ^[4] ; Marc,Zerbib ^[4] ; Audrey Thomas,Schoemann ^[5] ; Michel,Vidal ^[6] ; François,Goldwasser ^[2] ; Jérôme,Alexandre ^[2] ; Benoit,Blanchet ^[6]

作者单位： Department of Medical Oncology, Cochin Hospital, Paris Descartes University, CARPEM, AP-HP, Paris, France. Electronic address: joulia.marie@gmail.com. ^[1] Department of Medical Oncology, Cochin Hospital, Paris Descartes University, CARPEM, AP-HP, Paris, France. ^[2] Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France. ^[3] Department of Urology, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France. ^[4] Inserm U1268, CiTCom UMR8038 CNRS, Pharmacy UFR, University of Paris Descartes, PRES sorbonne Paris Cité, Paris, France; Department of Clinical Pharmacy, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France. ^[5] Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France; Inserm U1268, CiTCom UMR8038 CNRS, Pharmacy UFR, University of Paris Descartes, PRES sorbonne Paris Cité, Paris, France. ^[6]

关键词 Castration-resistant prostate cancer Enzalutamide N-desmethyl enzalutamide Pharmacodynamics Pharmacokinetics