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ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.

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第一作者: Zulekha A,Qadeer
第一单位: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Departments of Neurology, Neurosurgery, and Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA.
作者单位: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Departments of Neurology, Neurosurgery, and Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA. [1] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [2] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [3] Laboratory of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Institut de Recerca (VHIR), Barcelona 08035, Spain. [4] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [5] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. [6] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. [7] Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. [8] Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. [9] Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. [10] Pediatric Oncology and Hematology Department, University Hospital Vall d'Hebron, Barcelona 08035, Spain. [11] Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [12] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. [13] Center for Childhood Cancer Research at the Children's Hospital of Philadelphia, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. [14] Departments of Neurology, Neurosurgery, and Pediatrics, University of California, San Francisco, San Francisco, CA 94158, USA. [15] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [16] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: emily.bernstein@mssm.edu. [17]
DOI 10.1016/j.ccell.2019.09.002
PMID 31631027
发布时间 2022-07-16
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