Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge.

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作者： Andrea,Marzi ^[1] ; Pierce,Reynolds ^[2] ; Reinaldo,Mercado-Hernandez ^[2] ; Julie,Callison ^[2] ; Friederike,Feldmann ^[3] ; Rebecca,Rosenke ^[3] ; Tina,Thomas ^[2] ; Dana P,Scott ^[3] ; Patrick W,Hanley ^[3] ; Elaine,Haddock ^[2] ; Heinz,Feldmann ^[4]

作者单位： Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Electronic address: marzia@niaid.nih.gov. ^[1] Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. ^[2] Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. ^[3] Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Electronic address: feldmannh@niaid.nih.gov. ^[4]

关键词 EBOV-Makona Ebola virus Low-dose vaccination Macaque model VSV-EBOV

主题词动物(Animals);细胞因子类(Cytokines);剂量效应关系, 免疫(Dose-Response Relationship, Immunologic);埃博拉病毒(Ebolavirus);女(雌)性(Female);出血热, 埃博拉(Hemorrhagic Fever, Ebola);免疫, 体液(Immunity, Humoral);成束猴(Macaca fascicularis);男(雄)性(Male);存活率分析(Survival Analysis);接种(Vaccination);水疱病毒属(Vesiculovirus)

DOI 10.1016/j.ebiom.2019.09.055

PMID 31631035

发布时间 2020-03-31

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EBioMedicine

2019年49卷

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Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge.

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Single low-dose VSV-EBOV vaccination protects cynomolgus macaques from lethal Ebola challenge.

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