EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.

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第一作者： Lixian,Yang

第一单位： 1Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China.

作者： Lixian,Yang ^[1] ; Shilong,Ying ^[1] ; Shiman,Hu ^[1] ; Xiangtong,Zhao ^[1] ; Muchun,Li ^[1] ; Miaoqin,Chen ^[1] ; Yiran,Zhu ^[1] ; Ping,Song ^[2] ; Liyuan,Zhu ^[1] ; Tingting,Jiang ^[1] ; Huimin,An ^[3] ; Neelum Aziz,Yousafzai ^[2] ; Wenxia,Xu ^[1] ; Zhiguo,Zhang ^[4] ; Xian,Wang ^[2] ; Lifeng,Feng ^[1] ; Hongchuan,Jin ^[1]

作者单位： 1Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China. ^[1] 2Department of Medical Oncology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China. ^[2] 3Department of Pathology, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, China. ^[3] 4Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China. ^[4]

关键词 Cancer therapy Lung cancer

DOI 10.1038/s41392-019-0059-4

PMID 31637005

发布时间 2023-08-17

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Signal transduction and targeted therapy

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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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