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首页> Journal of human genetics> Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir.

Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir.

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作者： Jun,Matsumoto ^[1] ; Su Nwe,San ^[2] ; Masachika,Fujiyoshi ^[3] ; Ayano,Kawauchi ^[2] ; Natsumi,Chiba ^[2] ; Ran,Tagai ^[2] ; Ryoko,Sanbe ^[2] ; Shiho,Yanaka ^[2] ; Hiroaki,Sakaue ^[4] ; Yoshinori,Kato ^[2] ; Hiroyoshi,Nakamura ^[2] ; Harumi,Yamada ^[5] ; Noritaka,Ariyoshi ^[2]

作者单位： Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. matsumotoj@okayama-u.ac.jp. ^[1] Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare, Tochigi, Japan. ^[2] Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. ^[3] Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. ^[4] Division of Pharmacy, International University of Health and Welfare Mita Hospital, Tokyo, Japan. ^[5]

主题词抗病毒药(Antiviral Agents);苯丙氮|艹卓|类(Benzazepines);氨甲酸酯类(Carbamates);色谱法, 液相(Chromatography, Liquid);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);遗传变异(Genetic Variation);基因型(Genotype);人类(Humans);咪唑类(Imidazoles);吲哚类(Indoles);异喹啉类(Isoquinolines);肝(Liver);微粒体, 肝(Microsomes, Liver);吡咯烷类(Pyrrolidines);重组蛋白质类(Recombinant Proteins);磺胺类(Sulfonamides);串联质谱法(Tandem Mass Spectrometry);缬氨酸(Valine)

DOI 10.1038/s10038-019-0685-2

PMID 31645655

发布时间 2021-12-04

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Journal of human genetics

Journal of human genetics

2020年65卷2期

143-153页

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