Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.

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第一作者： Wen-Xue,Sun

第一单位： State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China.

作者： Wen-Xue,Sun ^[1] ; Hong-Wei,Han ^[1] ; Min-Kai,Yang ^[1] ; Zhong-Ling,Wen ^[1] ; Yin-Song,Wang ^[1] ; Jiang-Yan,Fu ^[1] ; Yun-Ting,Lu ^[1] ; Ming-Yue,Wang ^[1] ; Jia-Xin,Bao ^[1] ; Gui-Hua,Lu ^[1] ; Jin-Liang,Qi ^[2] ; Xiao-Ming,Wang ^[3] ; Hong-Yan,Lin ^[4] ; Yong-Hua,Yang ^[5]

作者单位： State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China. ^[1] State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: qijl@nju.edu.cn. ^[2] State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: wangxm07@nju.edu.cn. ^[3] State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: linhy@nju.edu.cn. ^[4] State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210023, PR China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: yangyh@nju.edu.cn. ^[5]