High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.

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作者： Katelyn M,Green ^[1] ; Udit J,Sheth ^[2] ; Brittany N,Flores ^[1] ; Shannon E,Wright ^[2] ; Alexandra B,Sutter ^[2] ; Michael G,Kearse ^[3] ; Sami J,Barmada ^[1] ; Magdalena I,Ivanova ^[4] ; Peter K,Todd ^[5]

作者单位： Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109. ^[1] Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109. ^[2] Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Department of Biological Chemistry and Pharmacology, Center for RNA Biology, Ohio State University, Columbus, Ohio 43210. ^[3] Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109. ^[4] Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109; Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105. Electronic address: petertod@umich.edu. ^[5]

关键词 C9orf72 FXTAS Lou Gehrig's disease RAN translation RNA amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease)drug screening neurodegeneration small molecule translation